Directions:
Start in San Juan.
Get onto PR-26 (Expreso Román Baldorioty de Castro) heading west toward Bayamón.
Merge onto PR-22 West (Expreso José de Diego).
Follow signs for Arecibo / Hatillo.
This is a toll highway, so make sure you have a AutoExpreso pass or cash.
Continue on PR-22 West for about 60 miles (95 km).
You’ll pass towns like Dorado, Vega Alta, Manatí, and Arecibo.
Enjoy the coastal views — it’s a scenic drive.
Take Exit 84B toward PR-113 / Isabela / PR-2 West.
Merge onto PR-2 West briefly.
Follow signs for Isabela.
After a few miles, take the PR-113 / PR-4494 exit toward downtown Isabela or your specific destination (beach area, town plaza, etc.).
Arrive in Isabela!
You can head to popular spots like Jobos Beach, Guajataca Tunnel, or Plaza de Isabela depending on your plans.